Scientists Identify an Antibody for Potential Tooth Regrowth

April 1, 2021

A new study has identified a potential antibody for a gene that can stimulate tooth growth.

A study by scientists at Kyoto University and the University of Fukui has found an antibody for a gene called uterine sensitization association gene-1 (USAG-1). This antibody has the potential to stimulate tooth growth in mice who are suffering from congenital conditions such as tooth agenesis, according to a press release from Kyoto University.

The molecules for tooth development have been identified as bone morphogenetic protein (BMP) and Wnt signaling. When targeting factors that agitate BMP and Wnt, the team thought about USAG-1. Investigating the antibodies for USAG-1, the team found that one specific antibody was able to generate a whole tooth in a mouse’s mouth.

Testing will continue on ferrets and other animals in the future to determine the benefits of antibodies on tooth regeneration.

To learn more about the study, visit here.